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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble

Shuang Yang,Yixiu Zhao,Xiaoling Cheng,Tingting Zhan,Jiaying Tian,Xue Liu,Chunyue Ma,Zhiqi Wang,Luying Jin,Qian Liu,Yanli Wang,Jian Huang,Jinhui Wang,Yan Zhang,Baofeng Yang,

Engineering doi: 10.1016/j.eng.2023.06.009

Abstract: Myocardial ischemia is a serious threat to human health, and vascular dysfunction is its main cause.Buxu Tongyu Granule (BXTY) is an effective traditional Chinese medicine (TCM) for treating myocardialIn this study, we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylateBXTY was given by gavage for ten consecutive days before establishing an animal model of acute myocardialIn conclusion, BXTY can improve the symptoms of acute myocardial ischemia in mice, and activating the

Keywords： Myocardial ischemia     Vasomotion     Soluble guanylate cyclase     Buxu Tongyu Granule    

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Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronaryartery disease by using intracoronary myocardial contrast echocardiography and two other angiographic

WANG Hong, HUANG Lan, JIN Jun, SONG Yaoming, GENG Zhaohua, YU Xuejun, QIN Jun, ZHAO Gang, GAO Yunhua, LIU Zheng

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 62-67 doi: 10.1007/s11684-007-0013-7

Abstract: Detection of abnormal myocardial perfusion is crucial to the prognosis of patients with coronary arteryThe objective of this study is to evaluate the effect of myocardial perfusion by three different methodsintra-coronary myocardial contrast echocardiography (ICMCE), corrected thrombolysis in myocardial infarctionblood volume, reperfusion velocity and myocardial blood flow, respectively.The myocardial blood volume and the myocardial blood flow of the IC-MCE quantitative parameters were
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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment. We tested the potential effect of apigenin, a natural flavonoid with anticancer, anti-inflammatory, and antioxidant activities, on neomycin-induced ototoxicity in cochlear hair cells in vitro. Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation of reactive oxygen species upon neomycin injury. Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway was activated by apigenin treatment. Disruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress and subsequent apoptosis of hair cells. This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying mechanism.

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 70-78 doi: 10.1007/s11684-020-0749-x

Abstract: Recent studies have shown that acute blood glucose elevation in patients with ST-segment elevation myocardial

Keywords： myocardial infarction     percutaneous coronary intervention     diabetes mellitus     fasting glucose     heart failure    

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Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 431-436 doi: 10.1007/s11684-009-0088-4

Abstract: The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardialRat models of myocardial hypertrophy were established by using abdominal aorta partial coarctation methodMyocardial fiber diameter (MFD) was examined by Hematoxylin-Eosin (HE) staining, and the contents ofIt was suggested that tanshinone II A could prevent myocardial hypertrophy by its action on the Akt signaling

Keywords： tanshinone II A     myocardial hypertrophy     rat     protein kinase B     abdominal aorta coarctation    

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Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 564-582 doi: 10.1007/s11684-019-0724-6

Abstract: Berberine, an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide rangeBerberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascularBerberine has protective capacities in digestive diseases.body weight, and alleviates nonalcoholic fatty liver disease.Furthermore, berberine exerts protective effects against other diseases.

Keywords： berberine     Coptis chinensis     pharmacological properties     mechanism     clinical applications    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: study was to explore the regulatory mechanism of retinoic acid (RA) on the TBX1 gene expression in myocardialThe expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredtreated with 3×10 mol/L RA, we observed that the expression of Shh mRNA and protein in neonatal rat myocardialThe results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardial

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 71-76 doi: 10.1007/s11684-010-0006-9

Abstract: evaluate the global and regional left ventricular twist by 2D strain in patients with anterior wall myocardial

Keywords： echocardiography     twist     two-dimensional strain imaging     coronary artery disease    

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A novel cataplasma matrix of traditional Chinese medicine

Jing TIAN, Xiaolei ZHANG, Xueqin ZHOU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 91-95 doi: 10.1007/s11705-009-0304-4

Abstract: Furthermore, the drug-compatibilities of the matrix were investigated with baicalin, berberine and curcuminrelease rate were measured as, 361.79, 55.85 and 104.41 μg·cm·hfor baicalin, berberine

Keywords： drug-release     applicable     berberine     curcumin     different    

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Pretreatment and copper recovery from chemosynthesis copper-containing berberine wastewater by Fe-C microelectrolysis

Zeng Ping,Song Yonghui,Cui Xiaoyu,Duan Liang,Qiu Guanglei,Xiao Shuhu,Ma Yinchen,Shan Yongping

Strategic Study of CAE 2013, Volume 15, Issue 3,   Pages 88-94

Abstract:

For the copper-containing berberine wastewater produced by pharmaceuticaloxygen demand (COD) concentration of 60 000~80 000 mg/L, copper concentration of 12 000~18 000 mg/L, berberineconcentration of 1 700~1 900 mg/L, the removal efficiencies of berberine and Cu2+ were higher than 99.0%, and the concentration of berberine and Cu2+ in effluent were lower than 1.0 mg/L and 0.5 mg/L after

Keywords： chemosynthesis pharmaceutical wastewater     Fe-C microelectrolysis     ion exchange column     berberine copper-containing    

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Application of Biomaterials in Cardiac Repair and Regeneration Review

Zhi Cui,Baofeng Yang,Ren-Ke Li

Engineering 2016, Volume 2, Issue 1,   Pages 141-148 doi: 10.1016/J.ENG.2016.01.028

Abstract:

Cardiovascular disease is a leading cause of death throughout the world. The demand for new therapeutic interventions is increasing. Although pharmacological and surgical interventions dramatically improve the quality of life of cardiovascular disease patients, cheaper and less invasive approaches are always preferable. Biomaterials, both natural and synthetic, exhibit great potential in cardiac repair and regeneration, either as a carrier for drug delivery or as an extracellular matrix substitute scaffold. In this review, we discuss the current treatment options for several cardiovascular diseases, as well as types of biomaterials that have been investigated as potential therapeutic interventions for said diseases. We especially highlight investigations into the possible use of conductive polymers for correcting ischemic heart disease-induced conduction abnormalities, and the generation of biological pacemakers to improve the conduction pathway in heart block.

Keywords： Myocardial infarction     Heart regeneration     Biomaterial     Tissue engineering     Stem cell    

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Pretreatment and copper recovery from chemosynthesis copper-containing berberine wastewater by Fe-C microelectrolysis

Lin Qi,Song Yonghui,Li Dong,Zhang Jie

Strategic Study of CAE 2013, Volume 15, Issue 3,   Pages 95-102

Abstract:

The wastewater treatment plant based on biological aerated filter faces the upgrading reconstruction to achieve the GB code first-level of wastewater discharge. Studies on the advanced treatment process involving chemical phosphorus removal, air-floated oil removal, hydrolysis acidification and the anoxic/oxic biological aerated filter were conducted, the feasibility of the process and the optimal parameters were determined. the feasibility of the process and the optimal parameters were determined. For pre-denitrification, the reflux ratio was 125 %, the hydraulic retention time was 20 min. The cost of construction and operation were calculated. The theoretical evidence and database can be used to the reference for the upgrading reconstruction of the similar wastewater treatment plant.

Keywords： industrial combined wastewater     wastewater treatment plant     biological aerated filter     upgrading reconstruction    

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CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Article

Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang

Engineering 2023, Volume 20, Issue 1,   Pages 49-62 doi: 10.1016/j.eng.2022.08.012

Abstract:

Myocardial infarction (MI), the most serious of the ischemic heart diseases, is accompanied by myocardial metabolic disorders and the loss of cardiomyocytes.This study aims to investigate the regulatory role and mechanisms of lncRNAs in myocardial remodelingAK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPAL), which is remarkably upregulated in the myocardial9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpin RNA (shRNA) partially abrogates myocardial

Keywords： Myocardial infarction     Pyroptosis     CPAL     NFκB     Inflammation    

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Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 416-437 doi: 10.1007/s11684-021-0852-7

Abstract: Precise understanding of myocardial adaptation to pressure and volume overloading and its responses tosurgery requires comprehensive assessments from aortic valve energy loss, valvular-vascular impedance to myocardialactivation, force-velocity relationship, and myocardial strain.LV hypertrophy and myocardial fibrosis remains as the structural and morphological focus in this endeavour

Keywords： valve replacement     trans-catheter aortic valve implantation     left ventricular hypertrophy and fibrosis     myocardial    

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Title Author Date Type Operation

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble

Shuang Yang,Yixiu Zhao,Xiaoling Cheng,Tingting Zhan,Jiaying Tian,Xue Liu,Chunyue Ma,Zhiqi Wang,Luying Jin,Qian Liu,Yanli Wang,Jian Huang,Jinhui Wang,Yan Zhang,Baofeng Yang,

Journal Article

Evaluation of the effect of myocardial perfusion after percutaneous coronary intervention in coronaryartery disease by using intracoronary myocardial contrast echocardiography and two other angiographic

WANG Hong, HUANG Lan, JIN Jun, SONG Yaoming, GENG Zhaohua, YU Xuejun, QIN Jun, ZHAO Gang, GAO Yunhua, LIU Zheng

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Journal Article

failure and left ventricular systolic dysfunction in non-diabetic patients with ST-segment elevation myocardial

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Journal Article

Protective effect of tanshinone II A on signal transduction system protein kinase B in rats with myocardial

Enyuan TU MD, Yongjun PAN MM, Kang ZHENG MM, Zhaohua WANG MD, Qiansheng LIANG MD, Guangtian YANG MD,

Journal Article

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

Assessment of global and regional left ventricular twist and displacement in anterior myocardial infarction

Wei HAN MM, Ming-Xing XIE MD, Qing LV MD, Xin-Fang WANG MD, Li ZHANG MM,

Journal Article

A novel cataplasma matrix of traditional Chinese medicine

Jing TIAN, Xiaolei ZHANG, Xueqin ZHOU,

Journal Article

Pretreatment and copper recovery from chemosynthesis copper-containing berberine wastewater by Fe-C microelectrolysis

Zeng Ping,Song Yonghui,Cui Xiaoyu,Duan Liang,Qiu Guanglei,Xiao Shuhu,Ma Yinchen,Shan Yongping

Journal Article

Application of Biomaterials in Cardiac Repair and Regeneration

Zhi Cui,Baofeng Yang,Ren-Ke Li

Journal Article

Pretreatment and copper recovery from chemosynthesis copper-containing berberine wastewater by Fe-C microelectrolysis

Lin Qi,Song Yonghui,Li Dong,Zhang Jie

Journal Article

CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction

Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang

Journal Article

Challenges and opportunities in improving left ventricular remodelling and clinical outcome following surgical and trans-catheter aortic valve replacement

Journal Article